Baldness Treatment
Its a statistical fact that more that half of the men on our planet are affected by baldess issues by the age of 45 and it is well-known that baldness treatments are evaluated to be a $1 000 000 000 per year industry.The war against baldness and hair issues is continuing for more than 25 years.Ever since the 1980s , medical treatment has increasingly become the best option for pattern baldness treatment.The role of dihydrotestosterone (aka DHT) was understood and this resulted in targeted intervention to prevent this hormone from working on receptors in the scalp.Finally ,after more than one quarter of a decade in researching and experimenting,the best baldness treatment medicament was invented.We will discuss this breakthrough treatment later in this article because now i want to talk about the developement of baldness-curing products through the years.
First i want to point your attention at the good old minoxidil.This probably is the first "famous" baldness treatment product.It is imprtant to say that at first minoxidil was used as a high blood pressure drug but after a series of tests it was discovered that this vasodilator has effect on hair regrowth and baldness reversing.This resulted in the creation of the first baldness treatment product ever - Rogaine from 1980's.This product contained 2% minoxidil.They used to apply it topically to the scalp areas (which is big disadvantage - there is no guarantee that 100% of the surface will be covered with the medicament) and even though it took several months to show effect , Rogaine showed great results for its time - there was hair growing in about 25% of the population.However this hair was more like baby's hair - thinner and lighter.Side effects were reported and it was well-known that this hair regrowth product causes skin irritation,increased heart rate and dizziness.Minoxidil stays the first , known to humanity , baldness treatment medicament.
The next group of medicaments i would like to explain is the so called Antiadrogens.They are used to block DHT ,that has already been created by our body,from inhibiting with hair roots.Their variety is great - from specific antiandrogens like finasteride (controls the change of testoterone into DHT) to wide spectrum antiandrogens (fluconazole and spironolactone for example).It is important to know that the second group of antiandrogens can have really serious side effects-gynecomastia.
-Finasteride-this is the name behind the well known brand-name Propecia.This medicament belongs to a group called aza-steroids and is a DHT Inhibitor.What is important for this product is that 1mg finasteride daily is enough to block almost 60% of DHT.A study that continued from 1997 up to 2002 discovered that 9 out of 10 men taking Propecia experienced great results.IMPORTANT: finasteride is only prescribed for men and pregnant women must not even get close to that medicament because there is big possibility that the chemicals in finasteride will harm their baby.
-Dutasteride - another aza-steroid released by the famous drug company GlaxoSmithKlein in 2001.Its marketing name is Avodart and just like finasteride ,it was originally created like a cure for benign prostatic hyperlasia.In 2006 GlaxoSmithKlein started a six months research in Korea to test the tolerability,effectiveness and safety of a daily dose of dutasteride.Till nowadays ,it is still unclear what will be FDA's decision - approval or disapproval of Avodart for the treatment of baldness in the US.
-Ketoconalo - a synthetic antifungal medicament used to treat and prevent skin infections.Most common it is used when the patients are immunocompromised - like those with AIDS or hepatitus.This drug is still unknown to the world and there are no signs that it will ever be.
Its a statistical fact that more that half of the men on our planet are affected by baldess issues by the age of 45 and it is well-known that baldness treatments are evaluated to be a $1 000 000 000 per year industry.The war against baldness and hair issues is continuing for more than 25 years.Ever since the 1980s , medical treatment has increasingly become the best option for pattern baldness treatment.The role of dihydrotestosterone (aka DHT) was understood and this resulted in targeted intervention to prevent this hormone from working on receptors in the scalp.Finally ,after more than one quarter of a decade in researching and experimenting,the best baldness treatment medicament was invented.We will discuss this breakthrough treatment later in this article because now i want to talk about the developement of baldness-curing products through the years.
First i want to point your attention at the good old minoxidil.This probably is the first "famous" baldness treatment product.It is imprtant to say that at first minoxidil was used as a high blood pressure drug but after a series of tests it was discovered that this vasodilator has effect on hair regrowth and baldness reversing.This resulted in the creation of the first baldness treatment product ever - Rogaine from 1980's.This product contained 2% minoxidil.They used to apply it topically to the scalp areas (which is big disadvantage - there is no guarantee that 100% of the surface will be covered with the medicament) and even though it took several months to show effect , Rogaine showed great results for its time - there was hair growing in about 25% of the population.However this hair was more like baby's hair - thinner and lighter.Side effects were reported and it was well-known that this hair regrowth product causes skin irritation,increased heart rate and dizziness.Minoxidil stays the first , known to humanity , baldness treatment medicament.
The next group of medicaments i would like to explain is the so called Antiadrogens.They are used to block DHT ,that has already been created by our body,from inhibiting with hair roots.Their variety is great - from specific antiandrogens like finasteride (controls the change of testoterone into DHT) to wide spectrum antiandrogens (fluconazole and spironolactone for example).It is important to know that the second group of antiandrogens can have really serious side effects-gynecomastia.
-Finasteride-this is the name behind the well known brand-name Propecia.This medicament belongs to a group called aza-steroids and is a DHT Inhibitor.What is important for this product is that 1mg finasteride daily is enough to block almost 60% of DHT.A study that continued from 1997 up to 2002 discovered that 9 out of 10 men taking Propecia experienced great results.IMPORTANT: finasteride is only prescribed for men and pregnant women must not even get close to that medicament because there is big possibility that the chemicals in finasteride will harm their baby.
-Dutasteride - another aza-steroid released by the famous drug company GlaxoSmithKlein in 2001.Its marketing name is Avodart and just like finasteride ,it was originally created like a cure for benign prostatic hyperlasia.In 2006 GlaxoSmithKlein started a six months research in Korea to test the tolerability,effectiveness and safety of a daily dose of dutasteride.Till nowadays ,it is still unclear what will be FDA's decision - approval or disapproval of Avodart for the treatment of baldness in the US.
-Ketoconalo - a synthetic antifungal medicament used to treat and prevent skin infections.Most common it is used when the patients are immunocompromised - like those with AIDS or hepatitus.This drug is still unknown to the world and there are no signs that it will ever be.
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